At KetaMed Infusions, we provide physician-led IV ketamine therapy for adults living with neuropathic pain that hasn’t responded to conventional treatments. Whether you’re dealing with diabetic neuropathy, post-surgical nerve pain, complex regional pain syndrome, or nerve injury-related pain, our team brings specialized expertise to help you find relief. As the first ketamine clinic on the Delmarva Peninsula, we’ve built our reputation on personalized care, medical excellence, and a genuine commitment to helping patients with complex nerve pain conditions.
Every treatment plan is tailored to your specific condition, symptoms, and response to therapy. We adjust your care based on what your body tells us—not on rigid protocols that treat everyone the same way.
Neuropathic pain results from damage to or dysfunction of the nervous system itself—either the peripheral nerves throughout your body or the central nervous system in your brain and spinal cord. Common causes include diabetes (diabetic neuropathy), surgery or injury that damages nerves, shingles (post-herpetic neuralgia), chemotherapy, autoimmune conditions, and nerve compression or entrapment. Unlike other types of pain, neuropathic pain is characterized by distinctive sensations: burning, tingling, shooting or stabbing pain, electric shock-like sensations, or pain triggered by normally non-painful stimuli like light touch or temperature changes.
The challenge with neuropathic pain is that it often resists the medications that work for other pain types. NSAIDs and opioids typically provide little relief because they don’t address the underlying nerve dysfunction. Even medications specifically designed for nerve pain—like gabapentin, pregabalin, or certain antidepressants—frequently fall short, leaving patients with persistent pain that impacts every aspect of daily life.
Ketamine was originally approved by the FDA as an anesthetic and has been used safely in medical settings for decades. At lower doses administered through IV infusion, ketamine has demonstrated significant effectiveness for treatment-resistant neuropathic pain. Unlike gabapentin, Lyrica, or tricyclic antidepressants that work through different mechanisms, ketamine is an NMDA receptor antagonist—meaning it directly blocks the receptors that play a key role in nerve pain amplification.
At KetaMed, we use IV ketamine as a targeted approach for neuropathic pain conditions that haven’t responded adequately to conventional treatments. This isn’t about temporarily masking symptoms—ketamine works to interrupt the pain amplification processes in your nervous system and help restore more normal pain processing. Research has shown that ketamine can be particularly effective for conditions like peripheral neuropathy, post-herpetic neuralgia, complex regional pain syndrome, and phantom limb pain.
Neuropathic pain involves complex changes in how your nervous system processes pain signals. When nerves are damaged or dysfunctional, NMDA receptors become overactive, driving a cycle of pain amplification. Glutamate, a key neurotransmitter, binds to these receptors and cranks up nerve hypersensitivity, making normal sensations feel painful and actual painful stimuli feel unbearable. This is why light touch can cause agony or why neuropathic pain often feels out of proportion to any visible injury.
Ketamine works by blocking NMDA receptors, which interrupts this pain amplification cycle, reduces glutamate-driven nerve hypersensitivity, provides anti-inflammatory effects at sites in the central nervous system, and helps restore more normal pain processing patterns. A comprehensive 2017 systematic review published in Anesthesia & Analgesia found that increased duration of relief from neuropathic pain was associated with higher total doses of ketamine, prolonged infusion durations, and coadministration of medications that helped manage side effects. A 2021 meta-analysis in PAIN journal demonstrated that chronic ketamine administration produced profound relief during treatment, with effects that could last weeks after infusion ended depending on treatment duration.
Your treatment begins with an initial consultation and comprehensive neuropathic pain evaluation. We’ll review your condition, previous treatments, current medications, and overall health to determine if IV ketamine is appropriate for your specific situation. Our goal is to understand your unique pain pattern and build a treatment plan that addresses your individual needs.
The treatment protocol for neuropathic pain often involves higher doses and more prolonged infusion protocols compared to other conditions, as research suggests this approach provides better and longer-lasting outcomes. The exact details of your treatment plan will be customized based on your condition and how you respond to therapy. Each infusion session takes place in our private, comfortable treatment rooms with continuous medical monitoring throughout. After each session, we’ll assess your response and adjust your care plan as needed. We also discuss maintenance therapy options to help sustain your results over the long term.
IV ketamine therapy may be appropriate if you’re living with peripheral neuropathy from diabetes or other causes, post-herpetic neuralgia (pain following shingles), complex regional pain syndrome (CRPS), phantom limb pain, or other nerve injury-related pain conditions. The best candidates are those whose pain hasn’t responded adequately to gabapentinoids (gabapentin, Lyrica), antidepressants, or other neuropathic pain medications, and who are seeking an alternative approach that works through a different mechanism.
This treatment may not be suitable for patients with certain cardiac conditions, uncontrolled high blood pressure, a history of psychosis or schizophrenia, or active substance use disorders. Every patient undergoes a thorough medical evaluation and screening process before beginning treatment to ensure both safety and appropriateness. It’s important to note that neuropathic pain treatment at KetaMed uses IV ketamine infusions only—not IM injections or oral troches.
At KetaMed, your safety and comfort are paramount. All IV ketamine infusions are supervised by licensed medical professionals with extensive experience in ketamine therapy for complex pain conditions. Your treatment takes place in private, calm rooms designed to help you feel relaxed and supported throughout your session. We provide continuous medical monitoring during every infusion to track your vital signs and ensure your safety.
Beyond the clinical protocols, we understand that living with neuropathic pain is exhausting, frustrating, and isolating. Many patients with nerve pain have been told there’s nothing more that can be done, or they’ve tried medication after medication without success. We’re here to offer genuine compassion, listen to your experience, and provide care that respects both your physical pain and the emotional toll it takes.
If you’re ready to explore whether IV ketamine therapy could help you find relief from nerve pain, we’re here to answer your questions and walk you through your options. There’s no pressure—just honest conversation about whether this treatment makes sense for your specific situation.
Conditions Treated
2324 North Zion Road Unit 113, Salisbury, MD
